Ms. Winehouse won awards in two of the three most prestigious categories, for the writing and recording of the single "Rehab," about her refusal to seek treatment for substance abuse. She performed on the program via satellite from London, where her tabloid-ready lifestyle recently prompted her to enter a rehabilitation center.

Looking stunned and strangely sad as she learned she had won for record of the year, she thanked her record label, her parents and "my Blake, my Blake incarcerated," referring to Blake Fielder-Civil, her husband, who has been jailed for his involvement in a pub brawl. Ms. Winehouse also won for best new artist, best female pop vocal performance for "Rehab" and best pop vocal album for her CD Back to Black.